Drosophila expressing human SOD1 successfully recapitulates mitochondrial phenotypic features of familial amyotrophic lateral sclerosis

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Drosophila expressing human SOD1 successfully recapitulates mitochondrial phenotypic features of familial amyotrophic lateral sclerosis

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作者：Xavier Gallart-Palau^a ; ^b ; ^c ; ^{xavgallart@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Chee-Hoe Ng^e ; ^f ; Joan Ribera^a ; ^b ; Siu Kwan Sze^c ; Kah-Leong Lim^d ; ^e ; ^f
关键词：FALS ; SOD1G93A ; Mitochondria ; Drosophila
刊名：Neuroscience Letters
出版年：2016
出版时间：15 June 2016
年：2016
卷：624
期：Complete
页码：47-52
全文大小：1650 K

文摘

•: Expression of SOD1^G93A in Drosophila thoracic muscles causes FALS phenotype.
•: 24B-GAL4-SOD1^G93A flies show impaired motor behavior and decreased lifespan.
•: 24B-GAL4-SOD1^G93A flies successful mimic mitochondrial dysfunction in FALS.
•: 24B-GAL4-SOD1^G93A represents novel therapeutic opportunities in FALS.

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