Axonal degeneration, distal collateral branching and neuromuscular junction architecture alterations occur prior to symptom onset in the SOD1<sup>G93A</sup> mouse model of amyotrophic lateral sclerosis

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Axonal degeneration, distal collateral branching and neuromuscular junction architecture alterations occur prior to symptom onset in the SOD1^G93A mouse model of amyotrophic lateral sclerosis

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作者：Jayden A. Clark^a ; ¹ ; Katherine A. Southam^a ; ¹ ; Catherine A. Blizzard^a ; Anna E. King^b ; Tracey C. Dickson^a ; ^{Tracey.Dickson@utas.edu.au" class="auth_mail" title="E-mail the corresponding author}
关键词：ALS ; amyotrophic lateral sclerosis ; NMJ ; neuromuscular junction ; SOD1 ; superoxide dismutase 1 gene ; SOD1G93A ; transgenic mouse model of ALS ; YFP ; yellow fluorescent protein
刊名：Journal of Chemical Neuroanatomy
出版年：2016
出版时间：October 2016
年：2016
卷：76
期：part_PA
页码：35-47
全文大小：2579 K

文摘

•: Axonal and NMJ pathology is present over the SOD1^G93A disease time-course.
•: NMJ morphology and branching alteration occurs prior to symptom onset.
•: NMJ architectural proteins are lost from the postsynaptic density.
•: NMJ architectural protein levels are increase and possibly misprocessed.