Naproxen as an alternative to aspirin for the treatment of arthritis of rheumatic fever: a randomized trial

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• 作者：Philip J. Hashkes ; Tsivia Tauber ; Eli Somekh ; Riva Brik ; Judith Barash ; Masza Mukamel ; Liora Harel ; Abraham Lorber ; Matityahu Berkovitch ; Yosef Uziel ; for the Pediatric Rheumatology Study Group of Israel
• 刊名：The Journal of Pediatrics
• 出版年：2003
• 出版时间：September 2003
• 年：2003
• 卷：143
• 期：3
• 页码：399-401
• 全文大小：88 K

文摘

We performed a prospective, randomized, open-label equivalence study comparing the use of naproxen to aspirin in 33 patients with rheumatic fever. The mean time until resolution of arthritis was 2.9±2.9 days in both groups. Liver enzyme elevations were more frequent in the aspirin group (P = .002). We conclude that naproxen is as effective, is easier to use, and is safer than aspirin in the treatment of the arthritis of rheumatic fever.