Exploring the chemopreventive properties and perspectives of baicalin and its aglycone baicalein in solid tumors

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• 作者：Wei-yi Gong^a ; ^b ; ¹ ; Zheng-xiao Zhao^a ; ^b ; ¹ ; Bao-jun Liu^a ; ^b ; Lin-wei Lu^a ; ^b ; Jing-cheng Dong^a ; ^b ; ^{jcdong2004@126.com}
• 关键词：Baicalin ; Baicalein ; Solid tumor ; Bioavailability
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：27 January 2017
• 年：2017
• 卷：126
• 期：Complete
• 页码：844-852
• 全文大小：1545 K
• 卷排序：126

文摘

●Baicalin and its aglycone baicalein have the potential roles in the treatment of cancer.●The mechanisms rely on apoptosis induction, autophagy triggering, cell cycle arrest, inhibition of 12-lipoxygenase and metastasis suppression.●New techniques to improve the bioavailability and reduce the side-effects of baicalin and baicalein should be taken into account in the future.