Modified live infectious bursal disease virus (IBDV) vaccine delays infection of neonatal broiler chickens with variant IBDV compared to turkey herpesvirus (HVT)-IBDV vectored vaccine

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• 作者：Shanika Kurukulasuriya^a ; Khawaja Ashfaque Ahmed^a ; Davor Ojkic^b ; Thushari Gunawardana^a ; Kalhari Goonewardene^a ; Ashish Gupta^a ; Betty Chow-Lockerbie^a ; Shelly Popowich^a ; Philip Willson^c ; Suresh K. Tikoo^d ; ^e ; Susantha Gomis^a ; ^{susantha.gomis@usask.ca}
• 关键词：Infectious bursal disease (IBD) ; VP2 hyper-variable domain ; Bursal atrophy ; Immunosuppression ; Maternal antibodies ; T-cell response
• 刊名：Vaccine
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：35
• 期：6
• 页码：882-888
• 全文大小：1358 K
• 卷排序：35

文摘

Modified live (MdLV) rather than HVT-IBDV vaccine delays neonatal varIBDV infection. varIBDV replicates early in HVT-IBDV compared to MdLV vaccinated chicks. HVT-IBDV vaccine induces suppression of T-cell response. First week after HVT-IBDV vaccination demands strict biosecurity.