Intronless and intron-containing type I IFN genes coexist in amphibian Xenopus tropicalis: Insights into the origin and evolution of type I IFNs in vertebrates

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• 作者：Zhen Gan^a ; ^b ; Shan Nan Chen^a ; Bei Huang^c ; Jing Hou^a ; ^b ; Pin Nie^a ; ^{pinnie@ihb.ac.cn} ; ^{pniefish@hotmail.com}
• 关键词：Type I IFN ; Intronless type I IFN ; Intron-containing type I IFN ; Retroposition event ; Xenopus tropicalis
• 刊名：Developmental & Comparative Immunology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：67
• 期：Complete
• 页码：166-176
• 全文大小：2434 K
• 卷排序：67

文摘

Intronless and intron-containing type I IFN genes coexist in Xenopus tropicalis. Intronless and intron-containing IFNs phylogenetically divide into three and two subgroups respectively. Different gene expression patterns were observed among subgroups of IFNs. Retroposition might have occurred in amphibians with the generation of IFNi genes. Models were proposed to explain the evolution of type I IFNs in vertebrates.