HCV-core and NS3 antigens play disparate role in inducing regulatory or effector T cells in vivo: Implications for viral persistence or clearance

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• 作者：Deepa K. Krishnadas ; Wen Li ; Rakesh Kumar ; D. Lorne Tyrrell ; Babita Agrawal
• 关键词：Hepatitis C virus (HCV) ; T lymphocyte activation ; Regulatory T cells ; Immune response ; Recombinant vaccinia virus
• 刊名：Vaccine
• 出版年：2010
• 出版时间：25 February 2010
• 年：2010
• 卷：28
• 期：9
• 页码：2104-2114
• 全文大小：1105 K

文摘

A distinguishing feature of HCV is its ability to persist in majority of the infected people. We investigated the role of HCV-core and NS3 in inducing effector T cells to mediate antiviral immunity. Our studies revealed that immunization with recombinant adenoviral vector containing HCV-core or NS3 leads to differential development of regulatory vs. effector T cells in mice, resulting in distinct outcomes of virus infection. For the first time, our studies directly demonstrate that HCV-core enhances both CD4⁺ and CD8⁺ T_regs which possibly contribute to persistent infection, whereas HCV NS3 induces both CD4⁺ and CD8⁺ effector T cells to allow viral clearance.