Phospholipid flippases DnfA and DnfB exhibit differential dynamics within the A. nidulans Spitzenkörper

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• 作者：Zachary Schultzhaus^a ; Wenhui Zheng^b ; Zonghua Wang^b ; Rosa Mouriñ ; o-Pé ; rez^c ; Brian Shaw^a ; ^{bdshaw@tamu.edu}
• 关键词：Secretion ; Hypha ; Polarization ; Endocytosis ; Microscopy
• 刊名：Fungal Genetics and Biology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：99
• 期：Complete
• 页码：26-28
• 全文大小：478 K
• 卷排序：99

文摘

DnfB localizes to the Spitzenkörper core and recovers faster than DnfA, which concentrates at the Spitzenkörper periphery. This may indicate secretory traffic from late Golgi is more rapid and abundant than traffic initiating from endocytosis. Glucan synthases subunit GsaA labels an unstable Spitzenkörper when dnfA is deleted. Endocytic and secretory machinery are depolarized to different extents in the absence of flippase β-subunit cdc50.