Knockout-Rescue Embryonic Stem Cell-Derived Mouse Reveals Circadian-Period Control by Quality and Quantity of CRY1

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• 作者：Koji L. Ode¹ ; ² ; ⁸ ; Hideki Ukai² ; ⁸ ; Etsuo A. Susaki¹ ; ² ; ³ ; ⁸ ; Ryohei Narumi² ; ⁹ ; Katsuhiko Matsumoto² ; Junko Hara² ; Naoshi Koide² ; Takaya Abe⁴ ; Masato T. Kanemaki³ ; ⁵ ; ⁶ ; Hiroshi Kiyonari⁴ ; ⁷ ; Hiroki R. Ueda¹ ; ² ; ¹⁰ ; ^{uedah-tky@umin.ac.jp}
• 关键词：circadian clock ; cryptochrome ; Cry1 ; phosphorylation ; knockin mouse ; ES mouse
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：65
• 期：1
• 页码：176-190
• 全文大小：10021 K
• 卷排序：65

文摘

A KO-rescue ES mouse method was developed to produce 20 different KO-rescue strains Multisite phosphorylation of CRY1 can serve as a cumulative timer CRY1-PER2 interaction confers a robust circadian rhythmicity in mice Flexible loops of CRY1 determine circadian period in mice without a turnover change