Non-local Concepts and Models in Biology

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• 作者：LEE ; C. T. ; HOOPES ; M. F. ; DIEHL ; J. ; GILLILAND ; W. ; HUXEL ; G. ; LEAVER ; E. V. ; MCCANN ; K. ; UMBANHOWAR ; J. ; et. al.
• 刊名：Journal of Theoretical Biology
• 出版年：2001
• 出版时间：May 21, 2001
• 年：2001
• 卷：210
• 期：2
• 页码：201-219
• 全文大小：348 K

文摘

In this paper, we consider local and non-local spatially explicit mathematical models for biological phenomena. We show that, when rate differences between fast and slow local dynamics are great enough, non-local models are adequate simplifications of local models. Non-local models thus avoid describing fast processes in mechanistic detail, instead describing the effects of fast processes on slower ones. As a consequence, non-local models are helpful to biologists because they describe biological systems on scales that are convenient to observation, data collection, and insight. We illustrate these arguments by comparing local and non-local models for the aggregation of hypothetical organisms, and we support theoretical ideas with concrete examples from cell biology and animal behavior.