Characterization and application of two RANK-specific antibodies with different biological activities

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Characterization and application of two RANK-specific antibodies with different biological activities

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作者：Mé ; lanie Chypre^a ; ^b ; Jonathan Seaman^c ; Olga G. Cordeiro^a ; Laure Willen^d ; Kathryn A. Knoop^e ; Andrew Buchanan^c ; Richard C.A. Sainson^c ; Ifor R. Williams^e ; Hideo Yagita^f ; Pascal Schneider^d ; Christopher G. Mueller^a ; ^{c.mueller@ibmc-cnrs.unistra.fr" class="auth_mail" title="E-mail the corresponding author}
关键词：RANK ; Receptor Activator of NF-κB ; OPG ; osteoprotegerin ; scFv ; single-chain variable fragment ; M cells ; microfold cells
刊名：Immunology Letters
出版年：2016
出版时间：March 2016
年：2016
卷：171
期：Complete
页码：5-14
全文大小：2311 K

文摘

•: Two RANK (TNFRSF11a)-specific monoclonal antibodies are characterized.
•: Both recognize human and mouse RANK with high specificity and affinity.
•: They are distinct by affinity and interference with receptor-ligand binding.
•: Human Langerhans cells highly express RANK.
•: The agonist antibody stimulates intestinal microfold cells in vivo.

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