Stacking with the unnatural DNA base 6-ethynylpyridone

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• 作者：Douglas J. Gibson ; Tanja van Mourik ; ^{tanja.vanmourik@st-andrews.ac.uk}
• 关键词：Unnatural base pair ; 6-Ethynylpyridone ; Density functional theory ; Stacking ; M06-2X ; BLYP-D3
• 刊名：Chemical Physics Letters
• 出版年：2017
• 出版时间：16 January 2017
• 年：2017
• 卷：668
• 期：Complete
• 页码：7-13
• 全文大小：1475 K
• 卷排序：668

文摘

An explanation is given for the increased stability of E:A-containing DNA duplexes. The increased stability is due to stronger base pairing and enhanced stacking. The enhanced stacking is only obtained in stacked base pairs.