Mitochondrial E3 ubiquitin ligase 1: A key enzyme in regulation of mitochondrial dynamics and functions

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Mitochondrial E3 ubiquitin ligase 1: A key enzyme in regulation of mitochondrial dynamics and functions

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作者：Jun Peng^a ; ^b ; ¹ ; Kai-Di Ren^b ; ¹ ; Jie Yang^c ; Xiu-Ju Luo^a ; ^{xjluo22@csu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：Mitochondrial E3 ubiquitin ligase 1 ; Ubiquitination ; SUMOylation ; Mitochondrial dynamic ; Apoptosis ; NF-κB
刊名：Mitochondrion
出版年：2016
出版时间：May 2016
年：2016
卷：28
期：Complete
页码：49-53
全文大小：410 K

文摘

•: Mul1 promotes mitochondrial fission through SUMOylation of Drp1.
•: Mul1 suppresses mitochondrial fusion through ubiquitination of Mfn2.
•: Mul1-mediated NF-κB activation exerts anti-apoptotic effect.
•: Mul1 involves in apoptosis or mitophagy through ubiquitination of AKT, ULK1, et al.
•: Mul1 involves in apoptosis or mitophagy through interaction with JNK or Ube2E3.

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