Anti-proliferation of breast cancer cells with itraconazole: Hedgehog pathway inhibition induces apoptosis and autophagic cell death

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• 作者：Xiaoya Wang^a ; ^b ; ¹ ; ^{543596983@qq.com} ; Sanhua Wei^c ; ¹ ; ^{Sanhuawei3@163.com} ; Yong Zhao^a ; ¹ ; ^{zhaoyong8@aliyun.com} ; Changhong Shi^a ; ^{changhong@fmmu.edu.cn} ; Peijuan Liu^a ; ^{liupeij1989077@126.com} ; Caiqin Zhang^a ; ^{zhangcaiqin-beibei@163.com} ; Yingfeng Lei^d ; ^{yflei@fmmu.edu.cn} ; Bo Zhang^e ; ^{zhangbo@fmmu.edu.cn} ; Bing Bai^a ; ^{bone_1999@163.com} ; Yong Huang^b ; ^{Yonghuang@nwsuaf.edu.cn} ; Hai Zhang^a ; ^{hzhang@fmmu.edu.cn}
• 关键词：Breast cancer ; Itraconazole ; Apoptosis ; Autophagic cell death ; Hedgehog pathway
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：28 January 2017
• 年：2017
• 卷：385
• 期：Complete
• 页码：128-136
• 全文大小：3801 K
• 卷排序：385

文摘

Itraconazole inhibited MCF-7 and SKBR-3 cells proliferation via induction of cell death and G0/G1 cell cycle arrest. Itraconazole treatment promoted apoptosis and autophagic cell death, which was regulated by Hedgehog pathway inhibition. Hedgehog pathway inhibitor GANT61 or SHH siRNA synergistically enhanced anti-proliferation effect induced by itraconazole. Anti-breast cancer activity of itraconazole or combined with GANT61 was confirmed in a human xenograft nude mouse model.