Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases

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Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases

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作者：Kimberly J. Zanotti ; Patricia J. Gearhart ; ^{gearhartp@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author}
关键词：AID ; activation-induced deaminase ; APE ; apurinic/apyrimidinic endonuclease ; BER ; base excision repair ; bp ; base pair ; CSR ; class switch recombination ; D ; diversity gene segment ; EXO1 ; exonuclease 1 ; Ig ; immunoglobulin ; J ; joining gene segment ; pol ; polymerase ; MMR ; mismatch repair ; NHEJ ; non-homologous end joining ; SHM ; somatic hypermutation ; SMUG1 ; single-strand-selective monofunctional uracil-DNA glycosylase ; UNG ; uracil DNA glycosylase ; V ; variable gene segment
刊名：DNA Repair
出版年：2016
出版时间：February 2016
年：2016
卷：38
期：Complete
页码：110-116
全文大小：379 K

文摘

•: Immunoglobulin diversification utilizes mismatch repair proteins at U:G mismatches.
•: MutSα and DNA polymerase η generate mutations during somatic hypermutation.
•: MutSα and MutLα regulate class switch recombination.

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