Archaeoglobus Fulgidus DNA Polymerase D: A Zinc-Binding Protein Inhibited by Hypoxanthine and Uracil

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Archaeoglobus Fulgidus DNA Polymerase D: A Zinc-Binding Protein Inhibited by Hypoxanthine and Uracil

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作者：Javier Abelló ; n-Ruiz ; Kevin J. Waldron ; Bernard A. Connolly ; ^{bernard.connolly@ncl.ac.uk" class="auth_mail" title="E-mail the corresponding author}
关键词：Pol-B ; family-B DNA polymerase ; Pol-D ; family-D DNA polymerase ; DP1 ; small (proofreading exonuclease) subunit of DNA polymerase D ; DP2 ; large (polymerase) subunit of DNA polymerase D ; Afu ; Archaeoglobus fulgidus ; Pfu ; Pyrococcus furiosus ; ICP-MS ; inductively coupled plasma mass spectroscopy
刊名：Journal of Molecular Biology
出版年：2016
出版时间：17 July 2016
年：2016
卷：428
期：14
页码：2805-2813
全文大小：1461 K

文摘

•: Archaeal DNA Polymerase-D binds Zn, this is essential for activity.
•: Archaeal DNA Polymerase-D is inhibited by uracil and hypoxanthine.
•: Inhibition by deaminated bases occurs both in cis and in trans.
•: Deaminated bases are sensed by the large (polymerase) subunit.
•: Polymerase-D has high fidelity, compatible with genome replication.

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