Ku antigen displays the AP lyase activity on a certain type of duplex DNA

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Ku antigen displays the AP lyase activity on a certain type of duplex DNA

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作者：Anastasiya A. Kosova^a ; ¹ ; Svetlana N. Khodyreva^a ; ^b ; ¹ ; Olga I. Lavrik^a ; ^b ; ^{lavrik@niboch.nsc.ru" class="auth_mail" title="E-mail the corresponding author}
关键词：AP site ; apurinic/apyrimidinic site ; APE1 ; apurinic/apyrimidinic endonuclease 1 ; BER ; base excision repair ; dRP ; deoxyribose phosphate ; DSB ; double-strand break ; Endo III ; Escherichia coli endonuclease III ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; NHEJ ; nonhomologous end-joining ; PAGE ; polyacrylamide gel electrophoresis ; PNKP ; polynucleotide kinase 3ʹ-phosphatase ; Polβ ; DNA polymerase β ; TDP1 ; tyrosyl-DNA phosphodiesterase 1 ; Ung ; Escherichia coli uracil-DNA glycosylase
刊名：Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
出版年：2016
出版时间：September 2016
年：2016
卷：1864
期：9
页码：1244-1252
全文大小：914 K

文摘

•: Here Ku antigen interaction with AP DNA with protruding ends is studied in details.
•: The efficiency of Ku cross-linking with an AP site depends on DNA structure.
•: Ku cleaves AP sites in duplex DNA with protruding ends via β-elimination.
•: Ku prefers apurinic sites over apyrimidinic ones.
•: Ku can initiate the repair of AP sites.

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