Perturbation of genome integrity to fight pathogenic microorganisms

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• 作者：Kinga Nyí ; ri ; ^{nyiri.kinga@ttk.mta.hu} ; Beá ; ta G. Vé ; rtessy ; ^{vertessy@mail.bme.hu}
• 关键词：CH2THF ; 5 ; 10-methylene tetrahydrofolate ; DCD ; dCTP deaminase ; DCD-DUT ; bifunctional dCTP deaminase&ndash ; dUTPase ; DUT ; dUTPase ; DHF ; dihydrofolate ; DHFR ; dihydrofolate reductase ; DHFR&ndash ; TS ; bifunctional dihydrofolate reductase &ndash ; thymidylate synthase ; FAD ; flavin adenine dinucleotide ; SHMT ; serine hydroxymethyltransferase ; THF ; tetrahydrofolate ; TK ; thymidine kinase ; TS ; ThyX ; classical and flavin-dependent thymidylate synthase ; TMPK ; dTMP kinase ; Ugi ; uracil-DNA glycosylase inhibitor
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1861
• 期：1
• 页码：3593-3612
• 全文大小：1761 K
• 卷排序：1861

文摘

Critical assessment of approaches against enzymes in thymidylate biosynthesis Summary of dUTPase, thymidylate synthase and dihydrofolate reductase inhibitors Focus on the biomedically most challenging pathogens Identification of novel strategies by e.g. proteinaceous inhibition