A novel and label-free biosensors for uracil-DNA glycosylase activity based on the electrochemical oxidation of guanine bases at the graphene modified electrode

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A novel and label-free biosensors for uracil-DNA glycosylase activity based on the electrochemical oxidation of guanine bases at the graphene modified electrode

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作者：Feipeng Jiao^a ; Pin Qian^a ; Yun Qin^a ; Yalin Xia^b ; Chunyan Deng^a ; ^{dengchunyan@csu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Zhou Nie^b ; ^{niezhou.hnu@gmail.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Uracil-DNA glycosylase (UDG) ; Graphene ; Guanine
刊名：Talanta
出版年：2016
出版时间：15 January 2016
年：2016
卷：147
期：Complete
页码：98-102
全文大小：569 K

文摘

•: A novel biosensor for sensing uracil DNA glycosylase activity was developed.
•: The current responses of guanine bases in released ssDNA was as a signal indicator.
•: The electrochemical oxidation of guanine bases was greatly enhanced by graphene.
•: The label-free design did not need covalent attachment of redox indicator to DNA.
•: The UDG activity was simply determined with high sensitivity.

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