Homocysteine and hydrogen sulfide in epigenetic, metabolic and microbiota related renovascular hypertension

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Homocysteine and hydrogen sulfide in epigenetic, metabolic and microbiota related renovascular hypertension

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作者：Gregory J. Weber ; Sathnur Pushpakumar ; Suresh C. Tyagi ; Utpal Sen ; ^{u0sen001@louisville.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：3MST ; 3-mercaptopyruvate sulfurtransferase ; ACE2 ; angiotensin-converting enzyme 2 ; AGT ; angiotensinogen ; Ang-II ; angiotensin II ; AT1/T2-R ; angiotensin type-1/type-2 receptor ; BMI ; body mass index ; BP ; blood pressure ; CAT ; cysteine aminotransferase ; CBS ; cystathionine β-synthase ; CKD ; chronic kidney diseases ; CO ; carbon monoxide ; CRP ; C-reactive protein ; CSE ; cystathionine γ-lyase ; CVD ; cardiovascular disease ; DAO ; d-amino acid oxidase ; ECM ; extracellular matrix ; EMT ; epithelial-mesenchymal trans
刊名：Pharmacological Research
出版年：2016
出版时间：November 2016
年：2016
卷：113
期：part_PA
页码：300-312
全文大小：2211 K

文摘

•: H₂S attenuates RAS activity in the kidney, and therefore has potential to treat renovascular hypertension.
•: In metabolic and epigenetic hypermethylation diseases, H₂S deficiency exacerbates hypertension.
•: High homocysteine, and low H₂S is associated with CKD-mediated renovascular hypertension
•: Gut dysbiosis contributes to total plasma H₂S pool, and affects overall individual’s health.

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