Hyaluronidase splice variants are associated with histology and outcome in adenocarcinoma and squamous cell carcinoma of the lung

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• 作者：Vanessa Karen de S&#225 ; PhD^a ; Eloí ; sa Olivieri ; MSc^b ; Edwin Roger Parra ; MD ; PhD^a ; Alexandre Muxfeldt Ab'Saber ; MD ; PhD^a ; Teresa Takagaki ; MD ; PhD^c ; Fernando Augusto Soares ; MD ; PhD^b ; Dirce Carraro ; PhD^b ; Lina Carvalho ; MD ; PhD^d ; Vera Luiza Capelozzi ; MD ; PhD^a ; ^{vcapelozzi@lim05.fm.usp.br}
• 关键词：HAase ; Hyaluronidases ; HA ; Hyaluronan ; HYAL ; hyaluronidase gene ; LC ; Lung cancer
• 刊名：Human Pathology
• 出版年：2012
• 出版时间：May, 2012
• 年：2012
• 卷：43
• 期：5
• 页码：675-683
• 全文大小：1239 K

文摘

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Summary

Heterogeneity of hyaluronidase (HYAL) expression has been identified in tumors and shows promise as an indicator of disease progression. The expression profile of alternatively spliced forms of HYAL was evaluated in tumors and normal lung tissue from 69 resected tumors of patients with adenocarcinomas and squamous cell carcinomas. HYAL1-wild-type (wt) and variants 1 to 5, HYAL2-wt, and HYAL3-wt, and variants 1 to 3 were identified by polymerase chain reaction and direct sequencing. Different proportions of the 3 HYAL-wt and variants were expressed in tumor and normal lung tissues. HYAL1-wt was associated with a poorer prognosis and HYAL3-v1 with a better prognosis. HYAL splice variants are associated with histology and outcome, suggesting that strategies aimed at modulating their levels may be effective for lung cancer treatment.