Identification of a novel sildenafil analogue in an adulterated herbal supplement

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• 作者：Julie  ; Vaysse ; Vé ; ronique  ; Gilard ; Sté ; phane  ; Balayssac ; Chantal  ; Zedde ; Robert  ; Martino ; Myriam  ; Malet-Martino  ; ;   ; ^{martino@chimie.ups-tlse.fr}
• 关键词：Dietary supplement ; Adulterants ; Depiperazinothiosildenafil ; NMR ; MS
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2012
• 出版时间：5 February 2012
• 年：2012
• 卷：59
• 期：Complete
• 页码：58-66
• 全文大小：1087 K

文摘

iErect, a new dietary supplement marketed as ?00 % natural?and sold over the Internet, was analyzed. It contains thiosildenafil, a sildenafil analogue already reported as an adulterant in herbal formulations, and a new compound whose structure was elucidated after isolation using NMR, MS and IR. It was named depiperazinothiosildenafil as it results from the hydrolytic cleavage of the S¨CN bond of the sulfonamide group of thiosildenafil. A capsule of iErect contains a very high amount (?20 mg) of thiosildenafil and ?0 mg of depiperazinothiosildenafil, which places consumers at risk for potentially serious side-effects.