Cytotoxic eremophilane sesquiterpenoids from the saprobic fungus Berkleasmium nigroapicale

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• 作者：Masahiko Isaka ; Urarat Srisanoh ; Sukitaya Veeranondha ; Wilunda Choowong ; Saisamorn Lumyong
• 关键词：Berkleasmium nigroapicale ; Eremophilane ; Cytotoxicity ; Antimalarial activity ; Saprobic fungi
• 刊名：Tetrahedron
• 出版年：2009
• 出版时间：24 October 2009
• 年：2009
• 卷：65
• 期：43
• 页码：8808-8815
• 全文大小：371 K

文摘

Berkleasmins A–E, five new eremophilane sesquiterpenoids were isolated from the saprobic fungus Berkleasmium nigroapicale BCC 8220. The structures of the new compounds were elucidated by analyses of NMR spectroscopic and mass spectrometry data in combination with chemical means. Berkleasmins A and C exhibited cytotoxic activity against cancer cell-lines (NCI-H187, MCF-7, and KB) as well as nonmalignant Vero cells with IC₅₀ values of 1.1–7.5 μg/mL, and these compounds also showed antimalarial activity with respective IC₅₀ of 3.1 and 2.8 μg/mL.