Properties of poloxamer 407 and polysorbate mixed micelles: Influence of polysorbate hydrophobic chain

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• 作者：Dejan Ćirin ; ^{dejan.cirin@mf.uns.ac.rs} ; Veljko Krstono&scaron ; ić ; Mihalj Po&scaron ; a
• 关键词：Poloxamer ; Polysorbate ; Mixed micelles ; Regular solution theory ; Interactions
• 刊名：Journal of Industrial and Engineering Chemistry
• 出版年：2017
• 出版时间：25 March 2017
• 年：2017
• 卷：47
• 期：Complete
• 页码：194-201
• 全文大小：960 K
• 卷排序：47

文摘

In the present study, binary mixed micelles of poloxamer 407 and a homologous series of polysorbate surfactants (polysorbate 20, polysorbate 60, polysorbate 80, polysorbate 85) were investigated. Rubingh’s model was applied to determine the physicochemical parameters of the poloxamer/polysorbate binary systems. The obtained negative values of the interaction parameter and excess Gibbs energy showed the existence of synergism. By comparing the values of the investigated parameters, and the values of micropolarity measurements, it was noticed that the inclusion of polysorbate surfactants with longer and more saturated hydrophobic chains leads to improved packing in the micellar interior and stronger interactions.