Immunization with Leishmania donovani protein disulfide isomerase DNA construct induces Th1 and Th17 dependent immune response and protection against experimental visceral leishmaniasis in Balb/c mice

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• 作者：Ajay Amit<sup>asup> ; Vijayamahantesh<sup>asup><sup> ; sup><sup>csup> ; Manas R. Dikhit<sup>asup><sup> ; sup><sup>bsup> ; Ashish Kumar Singh<sup>asup><sup> ; sup><sup>dsup> ; Vikash Kumar<sup>asup> ; Shashi S. Suman<sup>fsup> ; Ashu Singh<sup>csup> ; Akhilesh Kumar<sup>asup> ; Ajit Kumar Thakur<sup>hsup> ; Vidyanand Ravi Das<sup>esup> ; Pradeep Das<sup>gsup> ; Sanjiva Bimal<sup>asup><sup> ; sup><sup>drsbimal24@yahoo.comsup><sup> ; sup><sup>drsanjiba.rmri@gmail.comsup>
• 关键词：Protein disulfide isomerase (PDI) ; DNA vaccine ; Interleukin (IL)-17A ; Nitric oxide ; Mitogen-activated protein kinase (MAPK) ; Visceral leishmaniasis ; Interferon gamma
• 刊名：Molecular Immunology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：82
• 期：Complete
• 页码：104-113
• 全文大小：2126 K
• 卷排序：82

文摘

Recombinant Leishmania donovani PDI is recognised in sera of VL patient. Immunization of BALB/c mice with LdPDI as DNA construct leads to enhance the T-cell proliferation. LdPDI-construct has the ability to trigger both Th17 and Th1 cells response in immunized mice. LdPDI-construct vaccination may ensure persistent IL-2 production and show high durability till a longer period of time.