Surgery of the head and neck in patient with Kniest dysplasia: Is wound healing an issue?

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• 作者：Qasim Husain^a ; Jungsuk Cho^b ; Jay Neugarten^b ; Vikash K. Modi^a ; ^{vkm2001@med.cornell.edu}
• 关键词：Kniest dysplasia ; Type II collagen ; COL2A1 mutation ; Wound healing ; Mandibular distraction ; Tracheotomy ; Cochlear implantation ; Cleft palate ; Laryngotracheal reconstruction ; Micrognathia
• 刊名：International Journal of Pediatric Otorhinolaryngology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：93
• 期：Complete
• 页码：97-99
• 全文大小：302 K
• 卷排序：93

文摘

Kniest dysplasia is a type II collagen disorder that arises from a genetic mutation of the COL2A1 gene that results in short stature, midface anomalies, tracheomalacia, and hearing loss. Disruption of the normal collagen pathway can lead to many changes given its critical role in the body, and can cause complications with respect to wound healing. We present a case in which a patient with Kniest dysplasia successfully underwent multiple procedures in the head and neck region including cochlear implantation, mandibular distraction, palatoplasty, and laryngotracheal reconstruction. All procedures did not have any associated complications with respect to wound healing, indicating that surgery in this population can take place as indicated and surgery should not be contraindicated or delayed.