Friedelane-type triterpenoids as selective anti-inflammatory agents by regulation of differential signaling pathways in LPS-stimulated macrophages

详细信息    查看全文

• 作者：Andrea Villar-Lorenzo^a ; ^b ; ^{avillar@iib.uam.es} ; Alejandro E. Ardiles^c ; ^d ; ¹ ; ^{ale_csic@gmail.com} ; Ana I. Arroba^a ; ^b ; ¹ ; ^{aarroba@iib.uam.es} ; Enrique Herná ; ndez-Jimé ; nez^e ; ^f ; ¹ ; ^{enheji@gmail.com} ; Virginia Pardo^a ; ^b ; ^{vpardo@iib.uam.es} ; Eduardo Ló ; pez-Collazo^e ; ^f ; ^{elopezc@salud.madrid.org} ; Ignacio A. Jimé ; nez^c ; ^{ignadiaz@gmail.com} ; Isabel L. Bazzocchi^c ; ^{ilopez@ull.es} ; Á ; gueda Gonzá ; lez-Rodrí ; guez^a ; ^b ; ² ; ^{aguedagr@iib.uam.es} ; Á ; ngela M. Valverde^a ; ^b ; ^{avalverde@iib.uam.es}
• 关键词：Macrophages ; Triterpenoids ; Inflammation ; Lipopolysaccharide ; Nitric oxide synthase ; Antioxidant enzymes
• 刊名：Toxicology and Applied Pharmacology
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：313
• 期：Complete
• 页码：57-67
• 全文大小：1755 K
• 卷排序：313

文摘

Compounds 18 (C18) and 25 (C25) exert anti-inflammatory effects in macrophages. C18 enhanced nuclear translocation of Nrf2 and increased HO1 expression. C25 inhibited the phosphorylation of JNK, p38 and ERK, members of the MAPKs family. C25 reduced LPS-mediated processing of caspase-1 and the cleavage of interleukin 1β. C18 and C25 may be therapeutic agents for diseases linked to inflammation.