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Objective
To delineate the panel of expression of phosphoinositide-specific phospholipase C (PI-PLC) signaling enzymes in normal endometrium and in endometriosis.
Design
Clinical/experimental study.
Setting
University.
Patient(s)
Healthy donor woman and endometriosis-affected woman.
Intervention(s)
Normal endometrium and endometriosis surgical biopsies were analyzed using gene expression analyses methodology (reverse transcriptase-polymerase chain reaction [PCR], bioanalyses).
Main Outcome Measure(s)
Gene expression (messenger RNA concentration) measures of 12 PI-PLC enzymes: PI-PLC ¦Â1, PI-PLC ¦Â2, PI-PLC ¦Â3, PI-PLC ¦Â4, PI-PLC ¦Ã1, PI-PLC ¦Ã2, PI-PLC ¦Ä1, PI-PLC ¦Ä3, PI-PLC ¦Ä4, PI-PLC ¦Å, PI-PLC ¦Ç1, and PI-PLC ¦Ç2.
Result(s)
PI-PLC ¦Â1, PI-PLC ¦Â3, PI-PLC ¦Ä1, and PI-PLC ¦Ä3 enzymes were detected, although differently expressed in normal and endometriosis tissues.
Conclusion(s)
The involvement of PI-PLC enzymes in inflammation and the consistency of susceptible endometriosis loci with PI-PLC genes mapping corroborate the hypothesis that PI signaling might be involved in the pathogenesis of endometriosis.
