TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells

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• 作者：Per Ludvik Brattå ; s¹ ; Marie E. Jö ; nsson¹ ; Liana Fasching¹ ; Jenny Nelander Wahlestedt⁴ ; Mansoureh Shahsavani² ; Ronny Falk² ; Anna Falk² ; Patric Jern³ ; Malin Parmar⁴ ; Johan Jakobsson¹ ; ⁵ ; ^{johan.jakobsson@med.lu.se}
• 关键词：human development ; transposable elements ; epigenetics ; neural stem cells ; gene regulation
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：18
• 期：1
• 页码：1-11
• 全文大小：2755 K
• 卷排序：18

文摘

Stage- and region-specific expression of ERVs during human brain development TRIM28 binds to ERVs and induces hetereochromatin in human neural progenitor cells Knockdown of TRIM28 in hNPCs results in the upregulation of ERV expression Protein-coding genes located near upregulated ERVs are upregulated