Polycyclic xanthones via pH-switched biotransformation of α-mangostin catalysed by horseradish peroxidase exhibited cytotoxicity against hepatoblastoma cells in vitro

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• 作者：Jia-Jia Wu ^{wujiajia1045529@163.com} ; Ting Ma ^{maxueting0842910@163.com} ; Zhi-Min Wang ^{418973903@qq.com} ; Wen-Jun Xu ^{cpu_xuwenjun@163.com} ; Xue-Lian Yang ^{792697415@qq.com} ; Jian-Guang Luo ^{luojg@cpu.edu.cn} ; Ling-Yi Kong ; ^{cpu_lykong@126.com} ; Xiao-Bing Wang ; ^{xbwang@cpu.edu.cn}
• 关键词：HRP ; horseradish peroxidase ; MMP ; mitochondrial membrane potential ; PARP ; poly-(ADP-ribose)-polymerase ; ROS ; reactive oxygen species ; MAPK ; mitogen-activated protein kinase ; ERK ; extracellular signal-regulated kinase ; JNK ; c-Jun N-terminal kinases ; p38 ; p38 mitogen-activated protein kinase ; Bax ; Bcl-2 Associated X Protein ; Bcl-2 ; B cell lymphoma/lewkmia-2
• 刊名：Journal of Functional Foods
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：28
• 期：Complete
• 页码：205-214
• 全文大小：2259 K
• 卷排序：28

文摘

Six xanthone analogues (1–6) were obtained in an environmental friendly way. Compound 1 with a peroxide group exhibited potent cytotoxic activity. Compound 1 induced G2/M arrest and activated caspase-dependent apoptotic pathway. Compound 1 inhibited the ROS-mediated and MAPK signalling pathway.