lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS

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• 作者：Danyang He¹ ; ² ; Jincheng Wang¹ ; ⁵ ; Yulan Lu³ ; Yaqi Deng¹ ; Chuntao Zhao¹ ; Lingli Xu¹ ; ³ ; Yinhuai Chen⁴ ; Yueh-Chiang Hu⁴ ; Wenhao Zhou³ ; Q. Richard Lu¹ ; ² ; ³ ; ⁶ ; ^{richard.lu@cchmc.org}
• 关键词：long noncoding RNA ; myelination ; remyelination ; chromatin remodeling ; neural precursors ; OPC ; oligodendrocyte differentiation ; functional genomics ; polycomb repressive complex ; EZH2
• 刊名：Neuron
• 出版年：2017
• 出版时间：18 January 2017
• 年：2017
• 卷：93
• 期：2
• 页码：362-378
• 全文大小：8644 K
• 卷排序：93

文摘

Transcriptome reconstruction reveals a dynamic network of lncRNAs in oligodendrocytes Identification of oligodendrocyte-enriched lncOLs critical for OPC differentiation Oligodendrocyte-restricted lncOL1 regulates timely CNS myelination and remyelination lncOL1 interacts with Suz12-PRC2 complex to orchestrate OPC differentiation program