Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell Apoptosis and Inhibition of Metastasis

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• 作者：Ravshan Burikhanov¹ ; ⁹ ; Nikhil Hebbar² ; ⁹ ; Sunil K. Noothi³ ; Nidhi Shukla² ; James Sledziona² ; Nathá ; lia Araujo² ; Meghana Kudrimoti¹ ; Qing Jun Wang² ; ⁴ ; David S. Watt⁴ ; ⁵ ; Danny R. Welch⁶ ; Jodi Maranchie⁷ ; Akihiro Harada⁸ ; Vivek M. Rangnekar¹ ; ² ; ³ ; ⁵ ; ¹⁰ ; ^{vmrang01@email.uky.edu}
• 关键词：chloroquine ; Par-4 ; p53 ; apoptosis ; Rab8b ; secretagogues ; metastasis-inhibition
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：18
• 期：2
• 页码：508-519
• 全文大小：3057 K
• 卷排序：18

文摘

Chloroquine induces the secretion of the tumor suppressor protein Par-4 Chloroquine-induced Par-4 secretion depends on p53 p53 directly induces Rab8b expression critical for Par-4 secretion Par-4 is essential for apoptosis and inhibition of tumor metastasis by chloroquine