Citrate and albumin facilitate transferrin iron loading in the presence of phosphate

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• 作者：Catalina Matias ; Devin W. Belnap ; Michael T. Smith ; Michael G. Stewart ; Isaac F. Torres ; Andrew J. Gross ; ^{agross1@roseman.edu} ; Richard K. Watt ; ^{rwatt@chem.byu.edu}
• 关键词：Non-transferrin bound iron ; Labile plasma iron ; Oxidative stress ; Inflammation ; Kidney disease ; Diabetes
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：168
• 期：Complete
• 页码：107-113
• 全文大小：869 K
• 卷排序：168

文摘

Labile plasma iron is present in serum of patients with inflammation. The reason labile plasma iron forms is unknown. Preformed Fe3 +-citrate loads iron into apo transferrin in the presence of phosphate Citrate or albumin help load Fe3 + into apo transferrin in the presence of phosphate Citrate and albumin maximizes Fe3 + loading into apo transferrin with phosphate