HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma

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HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma

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作者：Yanxin Pei¹ ; ² ; ¹³ ; Kun-Wei Liu¹ ; ¹³ ; Jun Wang¹ ; Alexandra Garancher¹ ; Ran Tao² ; Lourdes A. Esparza¹ ; Donna L. Maier¹ ; Yoko T. Udaka³ ; Najiba Murad² ; Sorana Morrissy⁴ ; Huriye Seker-Cin⁵ ; ⁶ ; Sebastian Brabetz⁵ ; ⁶ ; Lin Qi⁷ ; Mari Kogiso⁷ ; Simone Schubert⁸ ; James M. Olson⁹ ; Yoon-Jae Cho⁸ ; Xiao-Nan Li⁷ ; John R. Crawford³ ; ¹⁰ ; Michael L. Levy¹¹ ; Marcel Kool⁵ ; ⁶ ; Stefan M. Pfister⁵ ; ⁶ ; Michael D. Taylor⁴ ; ¹² ; Robert J. Wechsler-Reya¹ ; ^{rwreya@sbpdiscovery.org" class="auth_mail" title="E-mail the corresponding author}
刊名：Cancer Cell
出版年：2016
出版时间：14 March 2016
年：2016
卷：29
期：3
页码：311-323
全文大小：3540 K

文摘

•: High-throughput screening identifies inhibitors of MYC-driven MB
•: HDACIs inhibit growth of murine and human MYC-driven MB cells
•: HDACIs and PI3KIs cooperate to activate FOXO1 and suppress tumor growth in vitro
•: HDACIs and PI3KIs inhibit growth of MYC-driven tumors in vivo

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