Relating multi-sequence longitudinal intensity profiles and clinical covariates in incident multiple sclerosis lesions
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文摘

Pipeline to extract voxel level longitudinal profiles from four MRI sequences within lesion tissue

Propose two statistical models to relate clinical covariates to the longitudinal profiles

Develop a biomarker that identifies areas of slow, long-term intensity changes at a voxel level

We validate the biomarker with ratings by two expert MS clinicians

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