Isoform Switch of TET1 Regulates DNA Demethylation and Mouse Development

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• 作者：Wenhao Zhang¹ ; ¹⁰ ; Weikun Xia¹ ; ¹⁰ ; Qiujun Wang¹ ; Aaron J Towers² ; Jiayu Chen³ ; Rui Gao⁴ ; ⁵ ; Yu Zhang¹ ; Chia-an Yen⁶ ; Ah Young Lee⁶ ; Yuanyuan Li¹ ; Chen Zhou¹ ; Kaili Liu¹ ; Jing Zhang⁴ ; Tian-Peng Gu⁷ ; Xiuqi Chen¹ ; Zai Chang⁴ ; Danny Leung⁸ ; Shaorong Gao³ ; Yong-hui Jiang² ; ⁹ ; Wei Xie¹ ; ¹¹ ; ^{xiewei121@tsinghua.edu.cn}
• 关键词：Tet1 ; isoform switch ; DNA methylation ; imprinting ; epigenetics
• 刊名：Molecular Cell
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：64
• 期：6
• 页码：1062-1073
• 全文大小：2368 K
• 卷排序：64

文摘

Distinct isoforms of Tet1 are expressed in mouse early development and adult cells The N terminus of TET1 promotes its global chromatin binding Global and targeted chromatin binding for a regulator can be separated Exclusive expression of somatic Tet1 isoform results in defects in imprint erasure.