The Lumipulse G HBsAg-Quant assay for screening and quantification of the hepatitis B surface antigen

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The Lumipulse G HBsAg-Quant assay for screening and quantification of the hepatitis B surface antigen

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作者：Ruifeng Yang¹ ; ^{yangruifeng103@163.com" class="auth_mail" title="E-mail the corresponding author} ; Guangjun Song² ; ^{sguangjun2013@163.com" class="auth_mail" title="E-mail the corresponding author} ; Wenli Guan³ ; ^{1282071984@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Qian Wang³ ; ^{1520219971@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Yan Liu³ ; ^{helen_yan320@sohu.com" class="auth_mail" title="E-mail the corresponding author} ; Lai Wei ; ^{weilai@pkuph.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：HBV ; hepatitis B virus ; HBsAg ; hepatitis B surface antigen ; HBeAg ; hepatitis B e antigen ; anti-HBc ; antibodies against hepatitis B core antigen ; anti-HBs ; antibodies against hepatitis B surface antigen ; NAT ; nucleic acid testing ; CHB ; chronic hepatitis B ; HCC ; hepatocellular carcinoma ; OBI ; occult HBV infection ; PEG-IFN ; peginterferon ; NA ; nucleos(t)ide analogue ; ETV ; entecavir ; cccDNA ; covalently closed circular DNA ; CV ; coefficient of variation
刊名：Journal of Virological Methods
出版年：2016
出版时间：February 2016
年：2016
卷：228
期：Complete
页码：39-47
全文大小：1523 K

文摘

•: The Lumipulse HBsAg assay showed a detection limit of 0.005 IU/mL.
•: The assay identified 1% more clinical samples with trace amount of HBsAg.
•: The Lumipulse assay showed high correlation (R² ≥ 0.97, P < 0.01) with the Architect and Elecsys assays in quantifying HBsAg.
•: The Lumipulse assay yielded similar patterns of HBsAg fluctuation when used for the treatment monitoring as compared to the Architect and Elecsys assays.
•: HBsAg measured by the Lumipulse assay was slightly lower than that by the Architect (0.19 log10 IU/mL) and Elecsys assay (0.07 log10 IU/mL).

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