Chemosensitizing effect of Paris Saponin I on Camptothecin and 10-hydroxycamptothecin in lung cancer cells via p38 MAPK, ERK, and Akt signaling pathways

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• 作者：Zhen Liu^a ; Qi Zheng^a ; Wenzhu Chen^a ; Meng Wu^a ; Guojun Pan^a ; Ke Yang^a ; Xuzhe Li^a ; Shuli Man^a ; Yuou Teng^a ; Peng Yu^a ; ^{yupeng@tust.edu.cn} ; Wenyuan Gao^b ; ^{pharmgao@tju.edu.cn}
• 关键词：Paris Saponin I ; Camptothecin ; 10-Hydroxycamptothecin ; Lung cancer cells ; p38 MAPK ; ERK ; Akt
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：125
• 期：Complete
• 页码：760-769
• 全文大小：3187 K
• 卷排序：125

文摘

A combination of Paris Saponin I (PSI) and Camptothecin (CPT) was studied. A combination of PSI and 10-hydroxycamptothecin (HCPT) was studied. PSI enhanced the sensitivities of cancer cells to CPT/HCPT by inducing apoptosis. PSI sensitized lung cancer cells to CPT and HCPT via MAPKs and Akt pathways.