Convulsant and anticonvulsant effects of bupropion in mice

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• 作者：Tutka ; Piotr ; Barczynski ; Bartlomiej ; Wielosz ; Marian
• 关键词：Bupropion ; Seizure ; Antidepressant drug ; Smoking cessation ; Epilepsy
• 刊名：European Journal of Pharmacology
• 出版年：2004
• 出版时间：September 19, 2004
• 年：2004
• 卷：499
• 期：1-2
• 页码：117-120
• 全文大小：121 K

文摘

This study demonstrated that bupropion hydrochloride, an effective antidepressant and a commonly used smoking cessation aid, dose-dependently caused clonic convulsions in mice, with the CD₅₀ (convulsive dose₅₀, i.e., the dose producing convulsions in 50 % of mice) at 119.7 mg kg^aaa1. An evaluation for anticonvulsant effects showed that bupropion in the doses of 15aaa30 mg kg^aaa1 protected against convulsions induced by maximal electroshock with the ED₅₀ (effective dose₅₀, i.e., the dose protected 50 % of mice against convulsions) being 19.4 mg kg^aaa1. Bupropion had no effect on pentylenetetrazole- and kainic acid-induced convulsions. It is possible that the anticonvulsant activity of bupropion may be exploited for use in the treatment of epilepsy but it requires further investigations.