Pathway- and Cell-Specific Kappa-Opioid Receptor Modulation of Excitation-Inhibition Balance Differentially Gates D1 and D2 Accumbens Neuron Activity

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• 作者：Hugo A. Tejeda¹ ; Jocelyn Wu¹ ; Alana R. Kornspun¹ ; Marco Pignatelli¹ ; Vadim Kashtelyan² ; Michael J. Krashes¹ ; ³ ; Brad B. Lowell⁴ ; William A. Carlezon Jr.⁵ ; Antonello Bonci¹ ; ⁶ ; ⁷ ; ^{antonello.bonci@nih.gov}
• 关键词：GABA ; glutamate ; amygdala ; hippocampus ; dynorphin ; hypothalamus ; electrophysiology
• 刊名：Neuron
• 出版年：2017
• 出版时间：4 January 2017
• 年：2017
• 卷：93
• 期：1
• 页码：147-163
• 全文大小：5678 K
• 卷排序：93

文摘

NAcc KORs presynaptically inhibit glutamate synapses in a pathway-specific manner KORs inhibit D1 MSN collaterals more robustly than they inhibit D2 MSN collaterals KORs preferentially inhibit glutamate and GABA onto D1 and D2 MSNs, respectively KORs inhibit excitatory drive of D1 MSNs and disinhibit excitatory drive of D2 MSNs