Sarcomatoid lung carcinomas show high levels of programmed death ligand-1 (PD-L1) and strong immune-cell infiltration by TCD3 cells and macrophages

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Sarcomatoid lung carcinomas show high levels of programmed death ligand-1 (PD-L1) and strong immune-cell infiltration by TCD3 cells and macrophages

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作者：Thibault Vieira^a ; ^b ; Martine Antoine^a ; ^c ; Cé ; cile Hamard^a ; ^b ; Vincent Fallet^a ; ^b ; Michael Duruisseaux^a ; Nathalie Rabbe^a ; Anita Rodenas^c ; Jacques Cadranel^a ; ^b ; Marie Wislez^a ; ^b ; ^{marie.wislez@tnn.aphp.fr" class="auth_mail" title="E-mail the corresponding author}
关键词：Lung sarcomatoid carcinoma ; PD-L1 ; Tumor-Infiltrating lymphocytes ; Tumor-Infiltratingmacrophages ; Non-small-cell lung cancer
刊名：Lung Cancer
出版年：2016
出版时间：August 2016
年：2016
卷：98
期：Complete
页码：51-58
全文大小：1635 K

文摘

•: PD-L1, tumor-infiltrating lymphocytes (TIL) were higher in SC than in NSCLC.
•: High levels of TIL constituted a factor of good prognosis.
•: PD-L1 expression distinguishes subpopulations within tumor-infiltrating lymphocytes (CD3+ or CD4+) with different prognosis.
•: This result could represent a justification for the use of PD-L1/PD-1 immunotherapy.

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