Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis

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Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis

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作者：Mahesh S. Padanad¹ ; ² ; ¹² ; Georgia Konstantinidou¹ ; ² ; ¹² ; ¹³ ; Niranjan Venkateswaran¹ ; ² ; Margherita Melegari² ; Smita Rindhe¹ ; ² ; Matthew Mitsche³ ; ⁴ ; Chendong Yang⁵ ; Kimberly Batten⁶ ; Kenneth E. Huffman⁷ ; Jingwen Liu⁸ ; Ximing Tang⁹ ; Jaime Rodriguez-Canales⁹ ; Neda Kalhor⁹ ; Jerry W. Shay⁶ ; John D. Minna¹ ; ⁷ ; Jeffrey McDonald⁴ ; Ignacio I. Wistuba¹⁰ ; ¹¹ ; Ralph J. DeBerardinis³ ; ⁵ ; Pier Paolo Scaglioni¹ ; ² ; ^{pier.scaglioni@utsouthwestern.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：ACSL3 ; mutant KRAS ; lung cancer ; cancer metabolism ; fatty acid oxidation ; lipid metabolism ; mouse cancer models
刊名：Cell Reports
出版年：2016
出版时间：9 August 2016
年：2016
卷：16
期：6
页码：1614-1628
全文大小：5282 K

文摘

•: ACSL3 expression and activity in lung cancer cells is upregulated by mutant KRAS
•: ACSL3 suppression decreases β-oxidation and ATP levels in mutant KRAS lung cancer cells
•: ACSL3 is required for survival and oncogenic capacity of mutant KRAS lung cancer cells
•: ACSL3 is highly expressed in human lung cancer specimens and promotes cancer initiation

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