Brain inflammation, neurodegeneration and seizure development following picornavirus infection markedly differ among virus and mouse strains and substrains

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Brain inflammation, neurodegeneration and seizure development following picornavirus infection markedly differ among virus and mouse strains and substrains

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作者：Sonja Brö ; er^a ; Christopher Kä ; ufer^a ; ^b ; Verena Haist^c ; ¹ ; Lin Li^b ; ^c ; Ingo Gerhauser^c ; Muneeb Anjum^a ; ^b ; Marion Bankstahl^a ; ^b ; Wolfgang Baumgä ; rtner^b ; ^c ; Wolfgang Lö ; scher^a ; ^b ; ^{wolfgang.loescher@tiho-hannover.de" class="auth_mail" title="E-mail the corresponding author}
关键词：B6 ; C57BL/6 ; B6H ; C57BL/6JOlaHsd ; B6J ; C57BL/6J ; CNS ; central nervous system ; DA ; Daniel's ; DG ; dentate gyrus ; dpi ; days post-infection ; EEG ; electroencephalogram ; IFN ; interferon ; IL ; interleukin ; ISG ; interferon-stimulated gene ; NK ; natural killer ; OAS1 ; 2&prime ; 5&prime ; -oligoadenylate synthetase 1 ; PFU ; plaque-forming units ; pi ; post-infection ; PKR ; protein kinase R ; PMN ; polymorphonuclear leukocyte ; ROC ; receiver operating characteristic ; TCS ; total clinical score ; TMEV ; Theiler's murine enc
刊名：Experimental Neurology
出版年：2016
出版时间：May 2016
年：2016
卷：279
期：Complete
页码：57-74
全文大小：2895 K

文摘

•: Brain infection of C57BL/6 (B6) mice with Theiler's virus (TMEV) induces epilepsy.
•: We examined the response of two B6 substrains to three different TMEV (sub)strains.
•: Receiver operating characteristic (ROC) curve analysis was used for correlations.
•: Early and late seizures were observed with DA and a BeAn substrain of TMEV virus.
•: Markers of hippocampal inflammation and neurodegeneration correlated with ictogenesis.