Characterization of culture filtrate proteins Rv1197 and Rv1198 of ESAT-6 family from Mycobacterium tuberculosis H37Rv

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• 作者：Himanshu Pandey<sup>asup> ; Sarita Tripathi<sup>asup> ; Kanchan Srivastava<sup>csup> ; Dinesh K. Tripathi<sup>bsup> ; Mrigank Srivastava<sup>dsup> ; Surya Kant<sup>csup> ; Kishore K. Srivastava<sup>bsup><sup> ; sup><sup>kishore@cdri.res.insup> ; Ashish Arora<sup>asup><sup> ; sup><sup>ashish_arora@cdri.res.insup>
• 关键词：Mycobacterium tuberculosis ; ESAT-6 family ; Rv1197 ; Rv1198 ; Seroreactivity ; Vaccine
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1861
• 期：2
• 页码：396-408
• 全文大小：1332 K
• 卷排序：1861

文摘

Rv1197 and Rv1198 strongly interact to form a heterodimeric complex under reducing conditions. Strong humoral responses to Rv1197, Rv1198, CFP-10 and MoaC1 were found in patients with active pulmonary tuberculosis. Rv1198-FIA immunization induced a pro-inflammatory response with high levels TNF and IL-6.