The dynamic changes of X chromosome inactivation during early culture of human embryonic stem cells

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The dynamic changes of X chromosome inactivation during early culture of human embryonic stem cells

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作者：Pingyuan Xie^a ; ^b ; ^c ; ¹ ; Qi Ouyang^a ; ^b ; ^c ; ¹ ; Lizhi Leng^a ; ^c ; Liang Hu^a ; ^b ; ^c ; Dehua Cheng^a ; ^b ; ^c ; Yueqiu Tan^a ; ^b ; ^c ; Guangxiu Lu^b ; ^c ; Ge Lin^a ; ^b ; ^c ; ^{linggf@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
关键词：ihESCs ; initial human embryonic stem cells ; ehESCs ; early human embryonic stem cells ; XCI ; X chromosome inactivation ; Xi ; inactivated chromosome ; Xa ; activated chromosome ; SNP ; single-nucleotide polymorphism
刊名：Stem Cell Research
出版年：2016
出版时间：July 2016
年：2016
卷：17
期：1
页码：84-92
全文大小：1615 K

文摘

•: XCI dynamic change is a frequent epigenetic instability event during early hESC culture.
•: A subset of X-linked genes was up-regulated in ehESCs, including some cancer-related genes.
•: 5% oxygen was beneficial for XCI fidelity.

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