The Anti-Warburg Effect Elicited by the cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes

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• 作者：Fan Xing¹ ; ¹⁰ ; Yizhao Luan³ ; ⁴ ; ¹⁰ ; Jing Cai¹ ; ¹⁰ ; Sihan Wu¹ ; Jialuo Mai¹ ; Jiayu Gu¹ ; Haipeng Zhang¹ ; Kai Li¹ ; Yuan Lin¹ ; Xiao Xiao¹ ; Jiankai Liang¹ ; Yuan Li¹ ; Wenli Chen¹ ; Yaqian Tan¹ ; Longxiang Sheng¹ ; Bingzheng Lu¹ ; Wanjun Lu¹ ; Mingshi Gao¹ ; Pengxin Qiu¹ ; Xingwen Su¹ ; Wei Yin⁵ ; Jun Hu⁶ ; Zhongping Chen² ; ⁷ ; Ke Sai² ; ⁷ ; Jing Wang² ; ⁷ ; Furong Chen² ; ⁷ ; Yinsheng Chen² ; ⁷ ; Shida Zhu⁸ ; Dongbing Liu⁸ ; Shiyuan Cheng⁹ ; Zhi Xie³ ; ^{xiezhi@gmail.com} ; Wenbo Zhu¹ ; ^{zhuwenbo@mail.sysu.edu.cn} ; Guangmei Yan¹ ; ² ; ¹¹ ; ^{ygm@mail.sysu.edu.cn}
• 关键词：glioblastoma ; induced differentiation ; Warburg effect ; metabolic reprogramming ; oxidative phosphorylation ; glycolysis ; mitochondrial biogenesis ; cyclic adenosine monophosphate ; cAMP ; PPARγ coactivator-1α ; PGC1α
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：18
• 期：2
• 页码：468-481
• 全文大小：5627 K
• 卷排序：18

文摘

The anti-Warburg effect is elicited by cAMP activation in GBM cells Metabolic switch to oxidative phosphorylation drives the differentiation of GBM Mitochondrial biogenesis by cAMP activation triggers metabolic reprogramming The cAMP-CREB-PGC1α signal induces mitochondrial biogenesis and metabolic shift