Newcastle disease virus induces apoptosis in cisplatin-resistant human lung adenocarcinoma A549 cells in vitro and in vivo

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• 作者：Songshu Meng^a ; ^b ; ¹ ; Zhizhi Zhou^a ; ^b ; ¹ ; Fei Chen^b ; Xiangang Kong^a ; Huairan Liu^a ; Ke Jiang^c ; Wenbo Liu^c ; Maozhi Hu^c ; Xiaorong Zhang^c ; Chan Ding^d ; ^{shoveldeen@shvri.ac.cn} ; Yantao Wu^c ; ^{ytwu@yzu.edu.cn}
• 关键词：Newcastle disease virus (NDV) ; Cisplatin (DDP) ; Apoptosis ; Mitogen-activated protein kinase (MAPK) ; Akt
• 刊名：Cancer Letters
• 出版年：2012
• 出版时间：1 April 2012
• 年：2012
• 卷：317
• 期：1
• 页码：56-64
• 全文大小：1320 K

文摘

Cisplatin (DDP) is widely used in lung cancer chemotherapy. However, cisplatin resistance represents a major obstacle in effective clinical treatment. This study aims to investigate whether Newcastle disease virus (NDV) exhibits an oncolytic effect on cisplatin-resistant A549 lung cancer cells. We found that NDV induced A549/DDP cell apoptosis via the caspase pathway, particularly involving caspase-9, while the mitogen-activated protein kinase (MAPK) and Akt pathways also contributed to apoptotic induction. Furthermore, NDV displayed oncolytic effects in a mouse A549/DDP lung cancer model. Collectively, our data indicate that NDV could overcome the cisplatin resistance in lung cancer cells in vitro and in vivo.