Bererine induces peripheral lymphocytes immune regulations to realize its neuroprotective effects in the cerebral ischemia/reperfusion mice

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• 作者：Bing Song ; Xiangao Tang ; Xiaodong Wang ; Xiuyan Huang ; Yanxia Ye ; Xijian Lu ; Xiaohui Wei ; Yaoying Zeng
• 关键词：Ischemia/reperfusion ; Immunoregulation ; Activation ; Proliferation ; Cell cycle ; Apoptosis ; Inflammation cytokine
• 刊名：Cellular Immunology
• 出版年：2012
• 出版时间：March-April, 2012
• 年：2012
• 卷：276
• 期：1-2
• 页码：91-100
• 全文大小：1393 K

文摘

Previous studies have shown that Bererine (Ber) has significant neuroprotective effects and the present article aimed to investigate its mechanism from the aspect of peripheral immune system. We evaluated the effects of Ber 24 h after cerebral ischemia/reperfusion (I/R) on histologic injury in BALB/C mice and NOD-SCID (severe combined immunodeficient) mice lacking T and B cells. Infarct volume, neurological scores and brain water content were strikingly reduced by Ber in BALB/C mice versus NOD-SCID mice. Which suggested that Ber induces peripheral immune regulations to realize its neuroprotective effects in the cerebral I/R mice. Then we tested the lymphocytes from BALB/C lymph nodes (LNs) with their survival, activation, proliferation, cell cycle, apoptosis and differentiation induced by cytokine secretion to provide direct evidences that Ber realized its neuroprotective effects by regulating I/R-induced peripheral lymphocytes early immunoactivation and following immunotolerance and to better understand the importance of peripheral immune system following I/R insults.