The firing rates of pain-activated neurons in the LHb of depressed rats were increased

The percentage of c-Fos positive cells in LHb was significantly increased in rats receiving CUMS and pain stimulation

Antidepressant suppressed the firing rates of PANs and c-Fos expression by pain stimulation in LHb of depressed rats

The LHb lesion can improve both depression-like behavior and hyperalgesia in depressed rats with pain sensitivity

Hyperactivity of the LHb neurons contributes to depression-pain comorbidity in rats