The incorporation of daunorubicin in cancer cells through the use of titanium dioxide whiskers

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• 作者：Qingning Li ; Xuemei Wang ; Xiaohua Lu ; Honger Tian ; Hui Jiang ; Gang Lv ; Dadong Guo ; Chunhui Wu ; Baoan Chen
• 关键词：Titanium dioxide whiskers ; Titanium dioxide nanoparticles ; Ultra violet irradiation ; Photocatalysis ; Cancer therapy ; Drug delivery
• 刊名：Biomaterials
• 出版年：2009
• 出版时间：September 2009
• 年：2009
• 卷：30
• 期：27
• 页码：4708-4715
• 全文大小：751 K

文摘

Porous nanostructure with its unique properties is found to be able to hold promise in drug delivery. We fabricated the one-dimensional titanium dioxide whiskers (TiO₂ Ws) and designed a strategy to explore their drug delivery application and anti-tumor function combined with daunorubicin (DNR). We observed good biocompatibility of TiO₂ Ws and noted better photocatalytic activity. In human hepatocarcinoma cells (SMMC-7721 cells), TiO₂ Ws can obviously increase the intracellular concentration of DNR and enhance its potential anti-tumor efficiency, indicating TiO₂ Ws could produce an efficient drug delivery carrier effect importing DNR into target cells. Furthermore, its photocatalysis further led to the enhanced mortality of cancer cells under UV irradiation. These findings reveal that TiO₂ Ws-based delivery of anticancer drugs represents a promising approach in cancer therapy.